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PubMed · 1695968

[Morphological changes in leukocytes].

V S Ronin
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Abstract

The major inherited and acquired morphologic changes in the peripheral blood leukocytes are described. The diseases associated with such changes are enumerated and the author's observations are presented of a phenomenon of selected hyposegmentation of eosinophilic granulocyte nuclei and of some morphologic changes in these nuclei, that appear to be explained by their deranged maturation.

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Hematologic DiseasesHumansLeukocytesSyndromeEnglish AbstractJournal ArticleReview

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V S Ronin. 1990. [Morphological changes in leukocytes].. https://pubmed.ncbi.nlm.nih.gov/1695968/

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Exposure to organic solvents and risk of haematological malignancies.

Epidemiological studies indicating that exposure to organic solvents is a risk factor for haematological malignancies are reviewed. Exposure to benzene is a risk factor for ANLL. A preleukaemic phase with pancytopenia is common and may be associated with a normo- or hypercellular marrow with morphological characteristics suggesting MDS. There are indications that other organic solvents than benzene may be leukaemogenic. Certain chromosome aberrations are characteristic in leukaemic cells from solvent exposed ANLL patients. The average latency time from start of occupational exposure until diagnosis is about 10-11 years. There is epidemiological evidence that exposure to organic solvents may also increase the risk of lymphoproliferative malignancies, i.e. ALL, NHL, HD and myeloma.

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