Streptococcus suis sequence type 7 outbreak, Sichuan, China.

Changyun Ye; Xiaoping Zhu; Huaiqi Jing; Huamao Du; Mariela Segura; Han Zheng; Biao Kan; Lili Wang; Xuemei Bai; Yongyun Zhou; Zhigang Cui; Shouying Zhang; Dong Jin; Na Sun; Xia Luo; Ji Zhang; Zhaolong Gong; Xin Wang; Lei Wang; Hui Sun; Zhenjun Li; Qiangzheng Sun; Honglu Liu; Boqing Dong; Changwen Ke; Hui Yuan; Hua Wang; Kecheng Tian; Yu Wang; Marcelo Gottschalk; Jianguo Xu

doi:10.3201/eid1708.060232

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PubMed · 16965698

Streptococcus suis sequence type 7 outbreak, Sichuan, China.

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Abstract

An outbreak of Streptococcus suis serotype 2 emerged in the summer of 2005 in Sichuan Province, and sporadic infections occurred in 4 additional provinces of China. In total, 99 S. suis strains were isolated and analyzed in this study: 88 isolates from human patients and 11 from diseased pigs. We defined 98 of 99 isolates as pulse type I by using pulsed-field gel electrophoresis analysis of SmaI-digested chromosomal DNA. Furthermore, multilocus sequence typing classified 97 of 98 members of the pulse type I in the same sequence type (ST), ST-7. Isolates of ST-7 were more toxic to peripheral blood mononuclear cells than ST-1 strains. S. suis ST-7, the causative agent, was a single-locus variant of ST-1 with increased virulence. These findings strongly suggest that ST-7 is an emerging, highly virulent S. suis clone that caused the largest S. suis outbreak ever described.

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Animals China DNA, Bacterial Disease Outbreaks Electrophoresis, Gel, Pulsed-Field Humans Molecular Sequence Data Phylogeny Polymerase Chain Reaction Sequence Analysis, DNA Serotyping Streptococcal Infections Streptococcus suis Swine Swine Diseases Virulence Journal Article Research Support, Non-U.S. Gov't

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Changyun Ye, Xiaoping Zhu, Huaiqi Jing, Huamao Du, Mariela Segura, Han Zheng, Biao Kan, Lili Wang, Xuemei Bai, Yongyun Zhou, Zhigang Cui, Shouying Zhang, Dong Jin, Na Sun, Xia Luo, Ji Zhang, Zhaolong Gong, Xin Wang, Lei Wang, Hui Sun, Zhenjun Li, Qiangzheng Sun, Honglu Liu, Boqing Dong, Changwen Ke, Hui Yuan, Hua Wang, Kecheng Tian, Yu Wang, Marcelo Gottschalk, Jianguo Xu. 2006. Streptococcus suis sequence type 7 outbreak, Sichuan, China.. https://doi.org/10.3201/eid1708.060232

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