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Transimmunization for cutaneous T cell lymphoma: a Phase I study.

Michael Girardi·Carole L Berger·Lynn D Wilson·Inger R Christensen·Kacie R Thompson·Earl J Glusac·Richard L Edelson
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Abstract

Extracorporeal photochemotherapy (ECP) is a widely used immunotherapy for cutaneous T cell lymphoma (CTCL). It involves four sequential steps: conversion of blood monocytes into dendritic antigen presenting cells (DC) by repetitive adherence and disadherence to plastic surface; reinfusion of the new DC; presumed in vivo loading of the new DC with apoptotic malignant leukocytes; and expansion of the anti-tumor CD8 T cell pool. To assess the safety of a methodology designed to increase ex vivo contact between the apoptotic malignant cells and new DC prior to reinfusion, a single-center, open-label Phase I clinical study of a revised procedure--referred to as "Transimmunization"--was conducted in CTCL patients. Twenty-seven subjects were treated monthly for 3 to 5 months, alone or in combination with electron beam therapy. For those receiving Transimmunization alone, there was an overall diminution in infiltrative lesions in eleven (55%) of twenty patients. In the twelve leukemic CTCL patients, there was a significant mean reduction of 50.1% in the circulating malignant cells, as determined with family-specific anti-T cell receptor Vbeta monoclonal antibodies (P <or= 0.021). Because this therapy permits the synchronous induction and tumor loading of DC, with minimal toxicity, Transimmunization may merit further investigation in CTCL and other malignancies.

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AdultAgedAged, 80 and overAntigen PresentationCell Culture TechniquesCombined Modality TherapyDendritic CellsFemaleHumansImmunotherapy, AdoptiveLymphoma, T-Cell, CutaneousMaleMiddle AgedNeoplasm InvasivenessNeoplastic Cells, CirculatingPhotopheresisTreatment OutcomeClinical Trial, Phase IComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

Michael Girardi, Carole L Berger, Lynn D Wilson, Inger R Christensen, Kacie R Thompson, Earl J Glusac, Richard L Edelson. 2006. Transimmunization for cutaneous T cell lymphoma: a Phase I study.. https://doi.org/10.1080/10428190600581419

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