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Dactylitis: pathogenesis and clinical considerations.

Paul J Healy·Philip S Helliwell
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Abstract

Dactylitis is considered a hallmark feature of psoriatic arthritis (PsA), but it is found in other spondyloarthropathies, especially reactive arthritis, and other conditions (eg, sarcoidosis, gout, sickle cell disease, and a variety of infections). Dactylitis is difficult to define and assess with any level of consensus and consistency in PsA. A new objective measure has been developed to make assessment more uniform for clinical trials. The underlying pathophysiology has also been difficult to determine in spondyloarthropathy: synovitis, tenosynovitis, and enthesitis have all been recognized. The pathophysiology in other conditions varies but usually involves soft tissue and sometimes involves bone or joint. In non-spondyloarthropathies,treatment is determined by the underlying cause. Research on dactylitis treatment in PsA suffers from a paucity of trials and inconsistent outcome measurement. The only drug with good evidence of benefit from randomized controlled trials thus far is infliximab.

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Anti-Inflammatory Agents, Non-SteroidalArthritis, PsoriaticBiological FactorsFinger JointGlucocorticoidsHumansPrognosisJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Paul J Healy, Philip S Helliwell. 2006. Dactylitis: pathogenesis and clinical considerations.. https://doi.org/10.1007/s11926-006-0062-y

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