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PubMed · 16978536

DC-SIGN and immunoregulation.

Tong Zhou·Yongxi Chen·Li Hao·Yanyun Zhang
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Abstract

Dendritic cells (DCs) are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent studies because of its important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. These studies on DC-SIGN involved in primary and secondary immune response and relevant mechanism will certainly provide us with a new method in treating and preventing certain diseases.

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Cell Adhesion MoleculesDendritic CellsHumansImmunityLectins, C-TypeReceptors, Cell SurfaceReceptors, Pattern RecognitionTumor EscapeDC-Specific ICAM-3 Grabbing NonintegrinJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Tong Zhou, Yongxi Chen, Li Hao, Yanyun Zhang. 2006. DC-SIGN and immunoregulation.. https://pubmed.ncbi.nlm.nih.gov/16978536/

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