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Essential genes on metabolic maps.

Svetlana Gerdes·Robert Edwards·Michael Kubal·Michael Fonstein·Rick Stevens·Andrei Osterman
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Abstract

Within the past five years genome-scale gene essentiality data sets have been published for ten diverse bacterial species. These data are a rich source of information about cellular networks that we are only beginning to explore. The analysis of these data, very heterogeneous in nature, is a challenging task. Even the definition of 'essential genes' in various genome-scale studies varies from genes 'absolutely required for survival' to those 'strongly contributing to fitness' and robust competitive growth. A comparative analysis of gene essentiality across multiple organisms based on projection of experimentally observed essential genes to functional roles in a collection of metabolic pathways and subsystems is emerging as a powerful tool of systems biology.

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Computational BiologyDatabases, GeneticGenes, EssentialGenome, BacterialMetabolic Networks and PathwaysModels, BiologicalSystems BiologyJournal ArticleResearch Support, N.I.H., ExtramuralReview

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Svetlana Gerdes, Robert Edwards, Michael Kubal, Michael Fonstein, Rick Stevens, Andrei Osterman. 2006-09-15. Essential genes on metabolic maps.. https://doi.org/10.1016/j.copbio.2006.08.006

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