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PubMed · 16981823

Targeting the CB2 receptor for immune modulation.

Charles A Lunn·Eva-Pia Reich·Loretta Bober
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Abstract

Early work on the biology of the components of Cannabis sativa showed evidence for a potential influence on immune regulation. With the discovery of a peripheral cannabinoid receptor associated with immune cells, many laboratories have sought to link the immunoregulatory activities of cannabinoid compounds with this receptor, hoping that such compounds would lack the psychoactive effects of marijuana and other nonspecific cannabinoid agonists. In this report, the authors investigate the role of the cannabinoid CB2 receptor in immune regulation, with particular emphasis on compounds shown to regulate immune cell recruitment. The authors conclude by using the immune cell recruitment model to rationalise cannabinoid CB2 receptor-specific effects in modulating immune disease, particularly the increasing evidence for its role in experimental autoimmune encephalomyelitis and in influencing bone density.

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AnimalsCannabinoidsCannabisDrug Delivery SystemsHumansImmune System DiseasesReceptor, Cannabinoid, CB2Journal ArticleReview

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Charles A Lunn, Eva-Pia Reich, Loretta Bober. 2006. Targeting the CB2 receptor for immune modulation.. https://doi.org/10.1517/14728222.10.5.653

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