Pathway classification of TCA cycle.

S Pérès; M Beurton-Aimar; J P Mazat

doi:10.1049/ip-syb:20060013

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PubMed · 16986319

Pathway classification of TCA cycle.

S Pérès·M Beurton-Aimar·J P Mazat

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Abstract

The structural analysis of large metabolic networks exhibits a combinatorial explosion of elementary modes. A new method of classification has been developed [called aggregation around common motif (ACoM)], which groups elementary modes into classes with similar substructures. This method is applied to the tricarboxylic acid cycle and metabolite carriers. The analysis of this network evidences a great number of elementary flux modes (204) despite the low number of reactions (23). The ACoM is used to class these elementary modes in a low number of sets (8) with biological meanings.

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Adaptation, Physiological Algorithms Animals Cell Physiological Phenomena Citric Acid Cycle Computer Simulation Feedback Homeostasis Humans Kinetics Models, Biological Proteome Signal Transduction Journal Article

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S Pérès, M Beurton-Aimar, J P Mazat. 2006. Pathway classification of TCA cycle.. https://doi.org/10.1049/ip-syb%3A20060013

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