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PubMed · 16989525

Hydroxylated gedunin derivatives from Cedrela sinensis.

Kumiko Mitsui·Hiroaki Saito·Ryota Yamamura·Haruhiko Fukaya·Yukio Hitotsuyanagi·Koichi Takeya
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Abstract

Four new limonoids, 11alpha-hydroxygedunin (1), 11beta-hydroxygedunin (2), 7-deacetoxy-7alpha,11alpha-dihydroxygedunin (3), and 7-deacetoxy-7alpha,11beta-dihydroxygedunin (4), were isolated from the cortex of Cedrela sinensis, together with three known compounds, gedunin (5), 7-deacetoxy-7alpha-hydroxygedunin (6), and 11-oxogedunin (7). The structures of 1-4 were determined by a combination of 2D NMR experiments and chemical methods and by X-ray crystallography of 1 and 2.

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AnimalsAntineoplastic Agents, PhytogenicCedrelaCrystallography, X-RayDrug Screening Assays, AntitumorDrugs, Chinese HerbalInhibitory Concentration 50Leukemia P388LimoninsMiceMolecular ConformationMolecular StructureJournal Article

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Kumiko Mitsui, Hiroaki Saito, Ryota Yamamura, Haruhiko Fukaya, Yukio Hitotsuyanagi, Koichi Takeya. 2006. Hydroxylated gedunin derivatives from Cedrela sinensis.. https://doi.org/10.1021/np068021f

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