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PubMed · 16998536

Regulating insulin signaling and beta-cell function through IRS proteins.

Morris F White
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Abstract

Diabetes mellitus is a complex disorder that arises from various causes, including dysregulated glucose sensing and impaired insulin secretion (maturity onset diabetes of youth, MODY), autoimmune-mediated beta-cell destruction (type 1), or insufficient compensation for peripheral insulin resistance (type 2). Type 2 diabetes is the most prevalent form that usually occurs at middle age; it afflicts more than 30 million people over the age of 65, but is appearing with greater frequency in children and adolescents. Dysregulated insulin signaling exacerbated by chronic hyperglycemia promotes a cohort of systemic disorders--including dyslipidemia, hypertension, cardiovascular disease, and female infertility. Understanding the molecular basis of insulin resistance can prevent these disorders and their inevitable progression to type 2 diabetes.

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Diabetes MellitusHumansHyperglycemiaInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceInsulin-Secreting CellsIntracellular Signaling Peptides and ProteinsModels, BiologicalPhosphoproteinsSignal TransductionJournal ArticleReview

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BibTeXRIS

Morris F White. 2006. Regulating insulin signaling and beta-cell function through IRS proteins.. https://doi.org/10.1139/y06-008

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