BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network.

Xiaohui Chen; Ming Chen; Kaida Ning

doi:10.1093/bioinformatics/btl491

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BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network.

Xiaohui Chen·Ming Chen·Kaida Ning

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Abstract

UNLABELLED: BNArray is a systemized tool developed in R. It facilitates the construction of gene regulatory networks from DNA microarray data by using Bayesian network. Significant sub-modules of regulatory networks with high confidence are reconstructed by using our extended sub-network mining algorithm of directed graphs. BNArray can handle microarray datasets with missing data. To evaluate the statistical features of generated Bayesian networks, re-sampling procedures are utilized to yield collections of candidate 1st-order network sets for mining dense coherent sub-networks. AVAILABILITY: The R package and the supplementary documentation are available at http://www.cls.zju.edu.cn/binfo/BNArray/.

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Algorithms Bayes Theorem Computer Simulation Gene Expression Profiling Gene Expression Regulation Models, Biological Oligonucleotide Array Sequence Analysis Programming Languages Proteome Signal Transduction Software Journal Article Research Support, Non-U.S. Gov't

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Xiaohui Chen, Ming Chen, Kaida Ning. 2006-09-27. BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network.. https://doi.org/10.1093/bioinformatics%2Fbtl491

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