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PubMed · 1700595

Olfactory neuroblastoma. Additional immunohistochemical characterization.

H F Frierson·G W Ross·S E Mills·A Frankfurter
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Abstract

A panel of 12 antibodies was used to further characterize the immunohistochemical staining profile of olfactory neuroblastoma. The following results were obtained for the 11 neoplasms that were immunostained: neuron-specific enolase 11/11(+), S-100 protein 8/11(+), microtubule-associated protein-2 8/11(+), class III beta-tubulin isotype 9/11(+), neurofilament 200 kD 8/11(+), synaptophysin 7/11(+), glial fibrillary acidic protein 1/11(+), chromogranin A 1/11(+), vimentin 1/11(+), keratin (CAM 5.2) 4/11(+), keratin (AEI/AE3) 0/11(+), and epithelial membrane antigen 0/11(+). Expression of two intermediate filaments was found in 4 of the 11 tumors. The authors' data showing that 72% of olfactory neuroblastomas were S-100 protein positive and only one was immunoreactive for glial fibrillary acidic protein agree with other published immunohistochemical studies. With only a single exception, each of the 11 neoplasms was labeled with one or more antibodies that detect neuronal cytoskeletal proteins (class III beta-tubulin isotype, microtubule-associated protein-2, neurofilament 200 kD). These immunohistochemical results are complementary to the reported electron microscopic findings of intermediate filaments and microtubules in olfactory neuroblastomas.

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AdultAgedChromogranin AChromograninsFemaleGlial Fibrillary Acidic ProteinHumansImmunohistochemistryKeratinsMaleMembrane GlycoproteinsMembrane ProteinsMicrotubule-Associated ProteinsMiddle AgedMucin-1Nasopharyngeal NeoplasmsNeuroectodermal Tumors, Primitive, PeripheralPhosphopyruvate HydrataseS100 ProteinsSynaptophysinTubulinVimentinJournal Article

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H F Frierson, G W Ross, S E Mills, A Frankfurter. 1990. Olfactory neuroblastoma. Additional immunohistochemical characterization.. https://doi.org/10.1093/ajcp%2F94.5.547

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