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PubMed · 17009949

Active defense under oxidative stress. The antioxidant responsive element.

V V Lyakhovich·V A Vavilin·N K Zenkov·E B Menshchikova
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Abstract

This review considers the mechanisms and factors that stimulate transcription of genes regulated by the antioxidant responsive element (ARE). The latter is important for cell defense under conditions of oxidative stress and also for detoxification of electrophilic xenobiotics. There are differences in regulation of intracellular homeostasis involving Nrf2-mediated activation of ARE and other redox-sensitive factors (NF-kappaB and AP-1).

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AnimalsAntioxidantsGene Expression RegulationGlutaredoxinsGlutathione TransferaseHumansIntracellular Signaling Peptides and ProteinsIsothiocyanatesKelch-Like ECH-Associated Protein 1NAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2Oxidative StressOxidoreductasesPeroxidasesPeroxiredoxinsPhenolsQuinonesResponse ElementsThioredoxinsTranscription FactorsTranscription, GeneticXenobioticsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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V V Lyakhovich, V A Vavilin, N K Zenkov, E B Menshchikova. 2006. Active defense under oxidative stress. The antioxidant responsive element.. https://doi.org/10.1134/s0006297906090033

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