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PubMed · 17011764

TIM-3 in autoimmunity.

Ana C Anderson·David E Anderson
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Abstract

T cell immunoglobulin and mucin domain (TIM)-3 is a molecule expressed on terminally differentiated murine Th1 cells but not on Th2 cells. Identification of galectin-9 as a ligand for TIM-3 has now firmly established the TIM-3-galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. TIM-3 is similarly expressed on human Th1 cells and not on Th2 cells, which suggests that TIM-3 might also contribute to Th1 regulation in humans. In addition, genetic data associate the TIM locus and specific TIM-3 polymorphisms with various immune-mediated diseases. Most importantly, recent data suggest a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis.

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AnimalsAutoimmunityGalectinsHepatitis A Virus Cellular Receptor 2HumansImmune ToleranceMembrane ProteinsPolymorphism, GeneticReceptors, VirusTh1 CellsJournal ArticleReview

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Ana C Anderson, David E Anderson. 2006-10-02. TIM-3 in autoimmunity.. https://doi.org/10.1016/j.coi.2006.09.009

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