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PubMed · 17015012

Soluble guanylate cyclase.

Thomas L Poulos
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Abstract

Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep mechanism of sGC activation that involves at least two NO-binding sites. The crystal structure of a member of a recently discovered family of prokaryotic sGC homologues has provided important insights into structure-function relationships within the sGC family of proteins.

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AnimalsEnzyme ActivationGuanylate CyclaseHemeIn Vitro TechniquesKineticsLigandsModels, MolecularNitric OxideProkaryotic CellsRecombinant ProteinsSignal TransductionSolubilityJournal ArticleReview

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BibTeXRIS

Thomas L Poulos. 2006-10-02. Soluble guanylate cyclase.. https://doi.org/10.1016/j.sbi.2006.09.006

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