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PubMed · 17023092

Apolipoprotein E polymorphism and dendritic shape in hippocampal interneurons.

Bärbel Schönheit·Frauke Glöckner·Thomas G Ohm
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Abstract

The apolipoprotein E genetic polymorphism exerts a well described influence on Alzheimer's disease (AD) risk, although the pathogenetic mechanism is still not clear. Increasing evidence points to a diminished neuroplasticity in apolipoprotein E varepsilon4-allele carriers. But, alternatively or additionally, developmental differences in dendritic geometry may be associated with the polymorphism. We morphometrically examined the dendritic ramification of CA1 Parvalbumin-positive GABAergic hippocampal neurons (n=571) in matched pairs of aged non-demented individuals with different apolipoprotein E genotype. We chose Parvalbumin-positive interneurons since they lack potentially confounding AD-like cytoskeletal changes. To minimize the risk of transneuronal dendritic changes due to significant deafferentation we focused on non-demented individuals. In this chosen paradigm, neither the disease-associated apolipoprotein E varepsilon4-allele nor the apolipoprotein E varepsilon2-allele had a significant impact on dendritic shape when compared to the most common allelic variant apolipoprotein E varepsilon3/3. At least with respect to the studied cell type, the data suggest that the apolipoprotein E polymorphism does not modulate the original formation of dendrites in vivo, contrary to conclusions drawn from in vitro studies on neurite outgrowth.

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AgedAged, 80 and overAllelesApolipoproteins ECell ShapeDendritesFemaleHippocampusHumansInterneuronsMaleMiddle AgedNeuritesNeuronal PlasticityPolymorphism, GeneticComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Bärbel Schönheit, Frauke Glöckner, Thomas G Ohm. 2006-10-04. Apolipoprotein E polymorphism and dendritic shape in hippocampal interneurons.. https://doi.org/10.1016/j.neurobiolaging.2006.03.016

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