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PubMed · 17027219

[Optimal vancomycin serum level in Staphylococcus aureus infections?].

E Bingen·P Mariani-Kurkdjian·B Nebbad
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Abstract

Vancomycin is the cornerstone of therapy against methicillin-resistant Staphylococus aureus in both community and nosocomial-acquired infections. Because vancomycin is a concentration-independent or time-dependant antibiotic, most clinicians have abandoned the routine practice of determining peak serum concentrations to rely solely on monitoring serum concentrations. The so-called therapeutic range most often quoted for vancomycin was assessed for through serum concentrations of 5-10 mg/l. But prolonged exposure to serum concentration close to the MIC is associated with the emergence of resistance. More recent guidelines recommended vancomycin in concentrations of 15-20 mg/l for the treatment of severe Staphylococcus infections or in situations where vancomycin penetration is poor. However, because of the great variability of vancomycin MIC(S) (0,12-4 mg/l) of susceptible Staphylococcus strains, guidelines should recommend through serum concentrations of 5-10 times the MIC.

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Anti-Bacterial AgentsDose-Response Relationship, DrugHumansStaphylococcal InfectionsVancomycinEnglish AbstractJournal ArticleReview

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BibTeXRIS

E Bingen, P Mariani-Kurkdjian, B Nebbad. 2006-10-05. [Optimal vancomycin serum level in Staphylococcus aureus infections?].. https://doi.org/10.1016/j.medmal.2006.07.016

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