CLOCK leaves its mark on histones.

William J Belden; Jennifer J Loros; Jay C Dunlap

doi:10.1016/j.tibs.2006.09.009

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PubMed · 17027273

CLOCK leaves its mark on histones.

William J Belden·Jennifer J Loros·Jay C Dunlap

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Abstract

Transcriptional regulation of circadian rhythms in mammals involves a negative-feedback loop whereby a CLOCK-BMAL1 complex activates transcription of the genes encoding the proteins PER1 (Period 1), PER2, CRY1 (Cryptochrome 1) and CRY2, which feed back to inhibit the activity of CLOCK-BMAL1. It is becoming evident that chromatin remodeling has a crucial role in the transcriptional regulation of genes governing circadian rhythms. This is highlighted in a recent report that shows that CLOCK has histone acetyltransferase activity, thus, demonstrating that molecular components of the biological clock can themselves catalyze chromatin modifications.

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ARNTL Transcription Factors Animals Basic Helix-Loop-Helix Proteins CLOCK Proteins Chromatin Circadian Rhythm Gene Expression Regulation Histones Trans-Activators Transcription, Genetic Journal Article

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William J Belden, Jennifer J Loros, Jay C Dunlap. 2006-10-05. CLOCK leaves its mark on histones.. https://doi.org/10.1016/j.tibs.2006.09.009

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