Local infusion therapy in the monkey brainstem: technical considerations.

George I Jallo; Marc Becker; Ya J Liu; Benjamin S Carson; Michael Guarnieri

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PubMed · 17029190

Local infusion therapy in the monkey brainstem: technical considerations.

George I Jallo·Marc Becker·Ya J Liu·Benjamin S Carson·Michael Guarnieri

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Abstract

This chapter assesses the safety of freehand placement of an infusion catheter (outer diameter, 0.3 mm) in brainstems of cynomolgus monkeys (Macaca fascicularis) for local infusion therapy. A posterior midline approach through the cerebellum and roof of the fourth ventricle was used to implant catheters into a pontine target area. Computer tomography (CT), magnetic resonance imaging (MRI), and histology were used to examine the position of the implants. The freehand placement of a catheter resulted in approximately 5-mm variations in anterior-posterior and dorsal-ventral locations of the targeted implantation site. No evidence of morbidity from the surgery, or from the infusion process was present. In conclusion, small-diameter catheters for chronic drug infusions can be implanted safely into the brainstem, an eloquent region that has been considered surgically inoperable. Infusion systems may offer a minimally invasive, generally applicable tool to provide chronic therapy for central nervous system (CNS) lesions.

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Animals Antineoplastic Agents Brain Stem Neoplasms Catheterization Disease Models, Animal Infusions, Intralesional Macaca fascicularis Male Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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George I Jallo, Marc Becker, Ya J Liu, Benjamin S Carson, Michael Guarnieri. 2006. Local infusion therapy in the monkey brainstem: technical considerations.. https://pubmed.ncbi.nlm.nih.gov/17029190/

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