PubMed · 17029871
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A Watts, G Schwarz. 1997-06-30. Re: Manfred Eigen's 70th birthday.. https://doi.org/10.1016/s0301-4622(97)00074-4
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.