Therapeutic immunization for HIV.

Lindvi Gudmundsdotter; Anna Sjödin; Ann-Charlotte Boström; Bo Hejdeman; Rebecca Theve-Palm; Annette Alaeus; Knut Lidman; Britta Wahren

doi:10.1007/s00281-006-0029-0

PubMed · 17031650

Therapeutic immunization for HIV.

Lindvi Gudmundsdotter·Anna Sjödin·Ann-Charlotte Boström·Bo Hejdeman·Rebecca Theve-Palm·Annette Alaeus·Knut Lidman·Britta Wahren

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Abstract

Vaccines have entered into human clinical trials against infectious diseases and as therapies against cancer. The HIV virus establishes a latent infection at a very early stage and the T cell memory of the infected patient is rapidly destroyed. However, results of immunotherapy after DNA and protein immunization show that vaccine-induced immune responses might be present for a long period of time. Patients subjected to therapeutic immunization appear to do well, and to have a small immunological advantage, which, however, will have to be improved. The vaccine therapy should start early, while adequate reservoirs of appropriate T helper cells are available and still inducible. The DNA vaccines induce a relatively long-lived immunological memory, and gene-based immunization is effective in inducing cytotoxic CD8(+) T cells and CD4+ helper cells. Protein vaccines, on the other hand, primarily give T cell help. It thus appears that DNA and protein approaches to HIV immunization complement each other. A surprisingly broad reactivity to peptides from different subtypes of HIV was identified in individuals infected with several subtypes of HIV.

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AIDS Vaccines Adjuvants, Immunologic Antiretroviral Therapy, Highly Active CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Clinical Trials as Topic Cytokines HIV Antibodies HIV Infections Humans Immunologic Memory T-Lymphocytes Vaccines, DNA Viral Load Journal Article Review

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Lindvi Gudmundsdotter, Anna Sjödin, Ann-Charlotte Boström, Bo Hejdeman, Rebecca Theve-Palm, Annette Alaeus, Knut Lidman, Britta Wahren. 2006-10-10. Therapeutic immunization for HIV.. https://doi.org/10.1007/s00281-006-0029-0

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