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PubMed · 17031896

Nanostructured thermosensitive polymers with radical scavenging ability.

Guangchang Zhou·Issifu I Harruna·Weilie L Zhou·Wilhelm K Aicher·Kurt E Geckeler
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Abstract

The thermosensitive [60]fullerene end-capped poly(N-isopropylacrylamide) was successfully synthesized by the reaction of C(60) with dithiobenzoate-terminated poly(N-isopropylacrylamide), which was prepared by reversible addition-fragmentation chain-transfer (RAFT) polymerization in the presence of azobisisobutyronitrile (AIBN). Its structure was determined by FTIR, UV/Vis, and carbon and proton NMR spectroscopy as well as by size exclusion chromatography (SEC). The novel fullerenated polymer retained the thermosensitivity of poly(N-isopropylacrylamide). Moreover, it is soluble in water and most of the common organic solvents. Interestingly, it was able to form nanoparticle clusters in methanol and exhibited significant radical scavenging ability in cell viability and metabolic activity tests with fibroblasts and NOR-3 radicals.

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Acrylic ResinsAnimalsCell SurvivalChromatography, GelFibroblastsFree Radical ScavengersFullerenesMiceMicroscopy, Electron, TransmissionMolecular StructureNIH 3T3 CellsNanostructuresNitric Oxide DonorsNitrilesNitro CompoundsParticle SizePolymersSpectrophotometrySpectroscopy, Fourier Transform InfraredJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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BibTeXRIS

Guangchang Zhou, Issifu I Harruna, Weilie L Zhou, Wilhelm K Aicher, Kurt E Geckeler. 2007. Nanostructured thermosensitive polymers with radical scavenging ability.. https://doi.org/10.1002/chem.200600590

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