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PubMed · 17034462

Biologic agents in psoriasis.

Michael R Lee·Alan J Cooper
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Abstract

This paper reviews the new biologic agents that selectively block the immunologic steps implicated in the pathogenesis of psoriasis. Four strategies have been targeted: reduction of the number of pathogenic T cells; inhibition of T-cell activation and migration; modulation of the immune system; and blockage of the activity of inflammatory cytokines. There are three classes: monoclonal antibodies, fusion proteins and recombinant cytokines or growth factors. The actions, efficacy and side-effect profile of the biologic agents, alefacept, efalizumab, etanercept and infliximab, are reviewed.

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Antibodies, MonoclonalCytokinesHumansImmunologic FactorsIntercellular Signaling Peptides and ProteinsPsoriasisRecombinant Fusion ProteinsJournal ArticleReview

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BibTeXRIS

Michael R Lee, Alan J Cooper. 2006. Biologic agents in psoriasis.. https://doi.org/10.1111/j.1440-0960.2006.00286.x

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