From array to array: confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays.

Marek Skacel; Ana Siva; Bo Xu; Raymond R Tubbs

doi:10.1007/s10735-006-9051-8

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From array to array: confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays.

Marek Skacel·Ana Siva·Bo Xu·Raymond R Tubbs

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Abstract

The combination of array-based comparative genomic hybridization (CGH) with fluorescence in situ hybridization utilizing custom-designed bacterial artificial chromosome (BAC) probes applied to tissue microarrays represents a powerful compendium of techniques-greatly enhancing the throughput of genomic analysis and subsequent target validation. Such approach can be automated at various levels and allows managing large volume of targets and samples in a few experiments. As such, this approach facilitates discovery, validation and implementation of findings in the process of identification of new diagnostic, prognostic and potentially therapeutic molecular markers.

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DNA Genomics Humans In Situ Hybridization, Fluorescence Nucleic Acid Hybridization Tissue Array Analysis Comparative Study Journal Article

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Marek Skacel, Ana Siva, Bo Xu, Raymond R Tubbs. 2006-10-17. From array to array: confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays.. https://doi.org/10.1007/s10735-006-9051-8

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