Oxygen-exacerbated bleomycin pulmonary toxicity.

T S Ingrassia; J H Ryu; V F Trastek; E C Rosenow

doi:10.1016/s0025-6196(12)60489-3

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PubMed · 1704473

Oxygen-exacerbated bleomycin pulmonary toxicity.

T S Ingrassia·J H Ryu·V F Trastek·E C Rosenow

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Abstract

Bleomycin is an antineoplastic agent with potential for producing pulmonary toxicity, attributed in part to its free radical-promoting ability. Clinical and research experiences have suggested that the risk of bleomycin-induced pulmonary injury is increased with the administration of oxygen. We report a case in which the intraoperative administration of oxygen in the setting of previous bleomycin therapy contributed to postoperative ventilatory failure. Our patient recovered with corticosteroid therapy. Physician awareness of a potential interaction between oxygen and bleomycin may help reduce the morbidity and mortality related to bleomycin therapy.

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Acute Disease Adult Bleomycin Drug Synergism Humans Intraoperative Care Lung Neoplasms Male Neoplasm Recurrence, Local Neoplasms, Germ Cell and Embryonal Oxygen Inhalation Therapy Reoperation Respiratory Distress Syndrome Case Reports Journal Article Review

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T S Ingrassia, J H Ryu, V F Trastek, E C Rosenow. 1991. Oxygen-exacerbated bleomycin pulmonary toxicity.. https://doi.org/10.1016/s0025-6196(12)60489-3

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