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PubMed · 17048291

The oriented development of antituberculotics: salicylanilides.

Karel Waisser·Josef Matyk·Hana Divisová·Petra Husáková·Jirí Kunes·Vera Klimesová·Jarmila Kaustová·Ute Möllmann·Hans-Martin Dahse·Milan Miko
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Abstract

On the basis of our previous results 22 salicylanilides were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. The Free-Wilson method was used to evaluate structure-antimycobacterial activity relationships. 4-Chloro-N-(4-propylphenyl)salicylamide and 5-chloro-N-(4-propylphenyl)salicylamide were selected for preclinical studies.

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Antitubercular AgentsMicrobial Sensitivity TestsMycobacterium aviumMycobacterium kansasiiMycobacterium tuberculosisSalicylanilidesStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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Karel Waisser, Josef Matyk, Hana Divisová, Petra Husáková, Jirí Kunes, Vera Klimesová, Jarmila Kaustová, Ute Möllmann, Hans-Martin Dahse, Milan Miko. 2006. The oriented development of antituberculotics: salicylanilides.. https://doi.org/10.1002/ardp.200600093

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