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PubMed · 17052232

Active zone assembly and synaptic release.

R J Kittel·S Hallermann·S Thomsen·C Wichmann·S J Sigrist·M Heckmann
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Abstract

Neurotransmitter release at chemical synapses occurs when synaptic vesicles fuse to the presynaptic membrane at a specialized site termed the active zone. The depolarization-induced fusion is highly dependent on calcium ions, and, correspondingly, the transmission characteristics of synapses are thought to be influenced by the spatial arrangement of voltage-gated calcium channels with respect to vesicle release sites. Here, we review the involvement of the Drosophila Bruchpilot (BRP) protein in active zone assembly, a process that is required for the clustering of presynaptic calcium channels to ensure efficient vesicle release.

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AnimalsCalciumDrosophila ProteinsDrosophila melanogasterKineticsNeuromuscular JunctionProbabilitySynapsesSynaptic TransmissionJournal Article

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R J Kittel, S Hallermann, S Thomsen, C Wichmann, S J Sigrist, M Heckmann. 2006. Active zone assembly and synaptic release.. https://doi.org/10.1042/bst0340939

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