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PubMed · 17059989

Henle loop basement membrane as initial site for Randall plaque formation.

Vincenzo Sepe·Gabriella Adamo·Alfredo La Fianza·Carmelo Libetta·Maria G Giuliano·Grazia Soccio·Antonio Dal Canton
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Abstract

Since the early description of Randall plaques in 1937, studies of the pathogenesis of stone formation mainly focused on the chemistry involving salt precipitation and crystallization, rather than tubular and interstitial medullar mechanisms of calcium concentration and supersaturation. In 2003, Bushinsky published a suggestive and inspiring sequence of events aimed to show that the basement membrane of the thin limb of the loop of Henle can be the first site of nucleation, as recently shown by the impressive work by Evan et al. The aim of this minireview is to verify the consistency of the Evan and Bushinsky theory with the current literature in the field.

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Basement MembraneCalcium OxalateCalcium, DietaryChemical PrecipitationHumansKidney CalculiKidney Tubules, ProximalLoop of HenleMucoproteinsPhosphatesUrodynamicsUromodulinJournal ArticleReview

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Vincenzo Sepe, Gabriella Adamo, Alfredo La Fianza, Carmelo Libetta, Maria G Giuliano, Grazia Soccio, Antonio Dal Canton. 2006. Henle loop basement membrane as initial site for Randall plaque formation.. https://doi.org/10.1053/j.ajkd.2006.07.021

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