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PubMed · 17060974

HIV evolution and escape.

Douglas D Richman·Susan J Little·Davey M Smith·Terri Wrin·Christos Petropoulos·Joseph K Wong
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Abstract

Human immunodeficiency virus (HIV) exemplifies the principles of Darwinian evolution with a telescoped chronology. Because of its high mutation rate and remarkably high rates of replication, evolution can be appreciated over periods of days in contrast to the durations conceived of by Darwin. Certain selective pressures that drive the evolution of HIV include chemotherapy, anatomic compartmentalization and the immune response. Examples of these selective forces on HIV evolution are described.

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AIDS VaccinesBiological EvolutionDrug Resistance, ViralHIVHIV InfectionsHumansMutationSelection, GeneticVirus ReplicationJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Douglas D Richman, Susan J Little, Davey M Smith, Terri Wrin, Christos Petropoulos, Joseph K Wong. 2004. HIV evolution and escape.. https://pubmed.ncbi.nlm.nih.gov/17060974/

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