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PubMed · 17062882

Transcription factors regulating beta-cell function.

Marlon E Cerf
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Abstract

Type 2 diabetes is primarily associated with insulin resistance and beta-cell dysfunction. Maintenance of functional mature beta-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining beta-cell function. Defining the regulation of transcription factors as well as their regulation of important beta-cell genes like insulin will provide further insight into elucidating the mechanisms leading to beta-cell dysfunction.

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Basic Helix-Loop-Helix ProteinsEye ProteinsHepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 3-betaHomeodomain ProteinsHumansInsulin-Secreting CellsMaf Transcription FactorsNerve Tissue ProteinsPAX6 Transcription FactorPaired Box Transcription FactorsPancreasRepressor ProteinsTrans-ActivatorsTranscription FactorsJournal ArticleReview

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Marlon E Cerf. 2006. Transcription factors regulating beta-cell function.. https://doi.org/10.1530/eje.1.02277

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