Thymidine kinases in archaea.

A R Clausen; A Matakos; M P B Sandrini; J Piskur

doi:10.1080/15257770600894485

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Thymidine kinases in archaea.

A R Clausen·A Matakos·M P B Sandrini·J Piskur

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Abstract

Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum. The identified TK1s have high identity to Gram-positive bacteria TK1s. The TK1s from archaea, Gram-positive bacteria and eukaryotes share the same common ancestor, while the TK1s from Gram-negative bacteria belong to a less-related subgroup. It seems that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell.

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Amino Acid Sequence Animals Archaea Archaeal Proteins Bacterial Proteins Databases, Genetic Evolution, Molecular Gene Expression Regulation Humans Molecular Sequence Data Phosphotransferases (Alcohol Group Acceptor)Phylogeny Species Specificity Thymidine Kinase Journal Article

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A R Clausen, A Matakos, M P B Sandrini, J Piskur. 2006. Thymidine kinases in archaea.. https://doi.org/10.1080/15257770600894485

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