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PubMed · 17069848

Reperfusion injury: does it exist?

Garrett J Gross·John A Auchampach
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Abstract

It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se, still remains a controversial issue. In this review, we present mounting evidence supporting the concept that reperfusion injury exists, based on work conducted with adenosine and opioid receptor ligands, and the discovery of two new concepts regarding reperfusion injury: 'postconditioning' (POC) and the reperfusion injury salvage kinase (RISK) signaling pathway.

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AdenosineAnimalsHumansIschemic Preconditioning, MyocardialLigandsModels, CardiovascularMyocardial Reperfusion InjuryReceptors, OpioidReceptors, Purinergic P1Journal ArticleResearch Support, N.I.H., ExtramuralReview

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BibTeXRIS

Garrett J Gross, John A Auchampach. 2006-10-27. Reperfusion injury: does it exist?. https://doi.org/10.1016/j.yjmcc.2006.09.009

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