Functional interactions between calmodulin and estrogen receptor-alpha.

Lu Li; David B Sacks

doi:10.1016/j.cellsig.2006.08.018

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Functional interactions between calmodulin and estrogen receptor-alpha.

Lu Li·David B Sacks

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Abstract

The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor alpha and estrogen receptor beta (ERalpha and ERbeta). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERalpha. Calmodulin contributes to the regulation of both ERalpha degradation and ERalpha-mediated transcriptional activation. Recent data will be summarized in this review. Models to explain the molecular mechanisms by which calmodulin modulates ERalpha function are proposed.

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Animals Breast Neoplasms Calmodulin Estrogen Receptor alpha Female Gene Expression Regulation Humans Mammary Neoplasms, Animal Models, Biological Transcription, Genetic Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Lu Li, David B Sacks. 2006-10-27. Functional interactions between calmodulin and estrogen receptor-alpha.. https://doi.org/10.1016/j.cellsig.2006.08.018

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