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PubMed · 17071990

SAGE programs: model-free linkage analysis for complex cardiovascular phenotypes.

Shaoqi Rao·Qing K Wang
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Abstract

A complex disease trait refers to a phenotype that does not follow simple Mendelian segregation attributable to a single gene locus, but instead may be caused by multiple disease loci, their interactions, polygenic inheritance, and environmental effects. Most cardiovascular disorders are thought to have a polygenic basis with complex interactions with environmental factors. A gene that increases or decreases the risk to a complex cardiovascular disease (susceptibility gene) can now be mapped to a specific chromosomal region by model-free linkage analysis, and follow-up molecular genetic studies can identify the specific gene at the locus. This chapter describes a protocol for model-free linkage analysis of a complex trait, as implemented in the popular genetic analysis software-SAGE. In particular, the Haseman-Elston sib-pair regression method is introduced and implemented with examples to demonstrate how to identify susceptibility loci for complex traits.

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Cardiovascular DiseasesGenetic LinkageGenetic Predisposition to DiseaseHumansModels, GeneticPhenotypeRegression AnalysisSoftwareJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Shaoqi Rao, Qing K Wang. 2006. SAGE programs: model-free linkage analysis for complex cardiovascular phenotypes.. https://doi.org/10.1385/1-59745-159-2%3A61

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