STAT3-mediated anti-inflammatory signalling.

P J Murray

doi:10.1042/bst0341028

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PubMed · 17073743

STAT3-mediated anti-inflammatory signalling.

P J Murray

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Abstract

IL-1O (interleukin-10) negatively regulates inflammation through a mechanism that blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules required for the full activation of the innate and adaptive immune responses. The signalling pathway used by the IL-10 receptor to generate the anti-inflammatory response requires STAT3 (signal transducer and activator of transcription 3) and is indirect. Thus STAT3 activates other genes whose task is to selectively control transcription of inflammatory targets. Here, I summarize current knowledge of the key features of IL-10 signalling and make predictions concerning the mechanism of IL-10 at the level of inflammatory genes. Understanding IL-10 signalling should be a gateway to the development of broadly acting anti-inflammatory agents.

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Gene Expression Regulation Humans Infections Inflammation Interleukin-10 Models, Immunological Receptors, Interleukin-10 STAT3 Transcription Factor Signal Transduction Transcription, Genetic Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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P J Murray. 2006. STAT3-mediated anti-inflammatory signalling.. https://doi.org/10.1042/bst0341028

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