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PubMed · 17073748

Core promoter elements recognized by transcription factor IIB.

W Deng·S G E Roberts
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Abstract

The general transcription factor TFIIB (transcription factor IIB) plays a critical role in the assembly of the RNA polymerase II pre-initiation complex. TFIIB can make sequence-specific DNA contacts both upstream and downstream of the TATA box. This has led to the definition of two core promoter BREs (TFIIB-recognition elements), one upstream [BRE(u) (upstream BRE)] and one downstream of TATA box [BRE(d) (downstream BRE)]. TFIIB-BRE(u) and TFIIB-BRE(d) contacts are mediated by two independent DNA-recognition motifs within the core domain of TFIIB. Both the BRE(u) and the BRE(d) modulate the transcriptional potency of a promoter. However, the net effect of the BREs on promoter activity is dependent on the specific blend of elements present within a core promoter.

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Binding SitesPromoter Regions, GeneticRNA Polymerase IITATA BoxTranscription Factor TFIIBJournal ArticleResearch Support, Non-U.S. Gov't

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W Deng, S G E Roberts. 2006. Core promoter elements recognized by transcription factor IIB.. https://doi.org/10.1042/bst0341051

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