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PubMed · 17076244

[Preparation of puerarin solid self-microemulsion].

Ai-Hua Yu·Guang-Xi Zhai·Jing Cui·Hong Liu
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Abstract

OBJECTIVE: To prepare puerarin solid self-microemulsifying drug delivery system (SMEDDS). METHODS: Pseudo-ternary phase diagram was used to select the formula of microemulsion. The self-microemulsification efficiency was assessed, such as viscosity, conductance, refraction, zeta potential, size ditribution, dissolution were investigated. Puerarin were determined by UV to calculate the cumulative release at different time. RESULTS: The optimum formulation of puerarin solid self-microemulsifying drug delivery system the consisted of puerarin-Tween 800 glycerinum-ethyl oleate-water-Gum Acacia-manicol at weight ratio of 1.7: 16. 6: 16. 6: 16. 6 : 1.3: 4.0: 39.9: 19.9; Average particle diameter was 30 nm; The dissolution was 94.29% at 10 min. CONCLUSION: Stability of puerarin solid self-microemulsion drug delvery system is good, potent in improving the dissolution of puerarin.

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Biological AvailabilityDrug Delivery SystemsDrug StabilityEmulsionsIsoflavonesPlant RootsPlants, MedicinalPuerariaSolubilitySurface-Active AgentsWaterEnglish AbstractJournal Article

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Ai-Hua Yu, Guang-Xi Zhai, Jing Cui, Hong Liu. 2006. [Preparation of puerarin solid self-microemulsion].. https://pubmed.ncbi.nlm.nih.gov/17076244/

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