Structure and function of telomeres.

E H Blackburn

doi:10.1038/350569a0

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Structure and function of telomeres.

E H Blackburn

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Abstract

The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase, as well as its ability to form unusual structures in vitro. Moreover, telomere synthesis by telomerase has been shown to be essential for telomere maintenance and long-term viability.

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Animals Base Sequence Chromosomes DNA DNA Nucleotidylexotransferase Molecular Sequence Data RNA Journal Article Research Support, U.S. Gov't, P.H.S.Review

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E H Blackburn. 1991-04-18. Structure and function of telomeres.. https://doi.org/10.1038/350569a0

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