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PubMed · 17081673

Engineered internal noise stochastic resonator in gene network: a model study.

Zhiwei Wang·Zhonghuai Hou·Houwen Xin·Zhizhou Zhang
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Abstract

Based on a genetic bistable switch model coupled with a gene oscillator model, we have constructed a mesoscopic stochastic model for the coupled synthetic gene network, and studied how internal noise would influence the oscillation of such a system. We found that the state-to-state transitions can occur if the internal noise is taken into account, and the performance of resulting oscillation can reach a maximum in a certain internal noise level, which indicates the occurrence of internal noise stochastic resonance (SR) and makes the coupled gene network work as a stochastic resonator. The potential role of such an effect on gene expression systems is also discussed.

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Biological ClocksGene Regulatory NetworksModels, GeneticOscillometryStochastic ProcessesSystems BiologySystems TheoryJournal ArticleResearch Support, Non-U.S. Gov't

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Zhiwei Wang, Zhonghuai Hou, Houwen Xin, Zhizhou Zhang. 2006-09-14. Engineered internal noise stochastic resonator in gene network: a model study.. https://doi.org/10.1016/j.bpc.2006.09.006

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