Epac proteins: multi-purpose cAMP targets.

Johannes L Bos

doi:10.1016/j.tibs.2006.10.002

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Epac proteins: multi-purpose cAMP targets.

Johannes L Bos

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Abstract

Epac1 and Epac2 are cAMP-dependent guanine-nucleotide-exchange factors for the small GTPases Rap1 and Rap2, and are known to be important mediators of cAMP signaling. The recent determination of the crystal structure of Epac2 has indicated a mechanism for the activation of the multi-domain Epac proteins. In addition, these proteins have been implicated in various cellular processes such as integrin-mediated cell adhesion and cell-cell junction formation, the control of insulin secretion and neurotransmitter release. In most of these processes, cAMP signaling through protein kinase A (PKA) is also involved, stressing the interconnectivity between Epac- and PKA-mediated signaling.

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Animals Cell Adhesion Cyclic AMP Cyclic AMP-Dependent Protein Kinases Glucose Guanine Nucleotide Exchange Factors Humans Integrins Leukemia Inhibitory Factor Models, Biological Models, Chemical Protein Conformation Protein Structure, Tertiary Signal Transduction Journal Article Research Support, Non-U.S. Gov't Review

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Johannes L Bos. 2006-11-02. Epac proteins: multi-purpose cAMP targets.. https://doi.org/10.1016/j.tibs.2006.10.002

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