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Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

Anastassios V Tzingounis·Roger A Nicoll
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Abstract

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.

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AnimalsCytoskeletal ProteinsGene ExpressionMemoryNerve Tissue ProteinsNeuronal PlasticityJournal ArticleReview

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Anastassios V Tzingounis, Roger A Nicoll. 2006-11-09. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.. https://doi.org/10.1016/j.neuron.2006.10.016

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