Interactions between HIV-1 Tat and KSHV.

Y Aoki; G Tosato

doi:10.1007/978-3-540-34344-8_12

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PubMed · 17089803

Interactions between HIV-1 Tat and KSHV.

Y Aoki·G Tosato

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Abstract

Since the advent of the HIV-1 pandemic, a close association between HIV-1 infection and the development of selected types of cancers has been brought to light. The discovery of Kaposi sarcoma-associated herpesvirus (KSHV) has led to significant advances in uncovering the virological and molecular mechanisms involved in the pathogenesis of AIDS-related malignancies. Extensive evidence indicates that HIV-1 trans-activating protein Tat plays an oncogenic role in the development of KSHV-associated neoplasms. Comprehensive knowledge of the functions of Tat-1 together with the KSHV genes will contribute to a better understanding of the pathogenesis of virus-associated cancers and the interaction of viruses with their hosts.

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Amino Acid Sequence Animals Gene Products, tat HIV-1 HIV-2 Humans Molecular Sequence Data Sarcoma, Kaposi tat Gene Products, Human Immunodeficiency Virus Journal Article Review

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Y Aoki, G Tosato. 2007. Interactions between HIV-1 Tat and KSHV.. https://doi.org/10.1007/978-3-540-34344-8_12

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