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PubMed · 17091076

Prophylactic intravenous immune globulin and polymixin B decrease the incidence of septic episodes and hospital length of stay in severely burned children.

Jefferson M Lyons·Christopher Davis·Mary T Rieman·Robert Kopcha·Ho Phan·David Greenhalgh·Tina Palmieri·Richard Kagan
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Abstract

After burn shock resuscitation, serum gamma globulin levels decrease well below normal before slowly recovering over the course of 1 to 2 months. During this period, patients are vulnerable to further insult as a result of this immunocompromise. We hypothesized that intravenous immune globulin and subtherapeutic polymixin B (IVIG-B) could decrease the incidence and/or severity of sepsis after major thermal injury. A retrospective chart review from 1997 through 2003 at two hospitals compared patients who received IVIG-B (Hospital A) with those who did not (Hospital B). Patients with burns 40% or greater TBSA were included, whereas patients with nonsurvivable injuries were excluded from data analysis. A total of 152 patients were included in the study. One hundred two patients received IVIG-B, and 50 did not. Total burn size was 63.4% TBSA at Hospital A and 63.1% TBSA at Hospital B, with full-thickness burns of 54.4 and 61.7% TBSA, respectively (P < .05). Patients treated at Hospital A had a 51.9% incidence of inhalation injury compared with 28% of the patients at Hospital B (P < .05). There was an average of 1.2 and 1.9 septic episodes for patients treated at Hospital A and Hospital B, respectively (P < .05). Length of hospital stay was 77.1 days at Hospital A compared with 103.8 days at Hospital B (P < .05). Mortality was 17.6% and 18% at Hospitals A and B, respectively, and was not significantly different. Our data suggest that prophylactic IVIG-B is associated with a reduction in the incidence of septic episodes and decreased hospital length of stay following major thermal injury.

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Anti-Bacterial AgentsAntibiotic ProphylaxisBurnsChildFemaleHumansImmunoglobulins, IntravenousImmunologic FactorsLength of StayMalePolymyxin BRetrospective StudiesShock, SepticSmoke Inhalation InjuryTrauma Severity IndicesComparative StudyJournal ArticleMulticenter Study

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Jefferson M Lyons, Christopher Davis, Mary T Rieman, Robert Kopcha, Ho Phan, David Greenhalgh, Tina Palmieri, Richard Kagan. Prophylactic intravenous immune globulin and polymixin B decrease the incidence of septic episodes and hospital length of stay in severely burned children.. https://doi.org/10.1097/01.bcr.0000245421.54312.36

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