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PubMed · 17106921

Crohn's disease: innate immunodeficiency?

Jesus-K Yamamoto-Furusho·Joshua-R Korzenik
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Abstract

In the past, Crohn's disease (CD) has been understood primarily as an immunologic disorder characterized by an abnormal T-cell response. Recent in vitro and in vivo data suggests that CD may instead be precipitated by innate immune dysfunction resulting from a combination of genetic and environmental factors. Some reports have demonstrated a defective immune response in a variety of other cellular components, including neutrophils, monocytes and dendritic cells. Recent studies of granulocyte-macrophage colony-stimulating factor (GM-CSF) in CD, aiming to stimulate the innate immune system with the conception that an innate immune defect underlies the development of the disease, have been demonstrated a clinical benefit and reinforce this evolving understanding of the disease.

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Crohn DiseaseEnvironmentGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, InnateIntestinal MucosaNod2 Signaling Adaptor ProteinT-LymphocytesToll-Like ReceptorsJournal ArticleReview

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BibTeXRIS

Jesus-K Yamamoto-Furusho, Joshua-R Korzenik. 2006-11-14. Crohn's disease: innate immunodeficiency?. https://doi.org/10.3748/wjg.v12.i42.6751

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