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PubMed · 17109625

Neuronal semaphorins regulate a primary immune response.

Simona Moretti·Antonio Procopio·Massimo Boemi·Alfonso Catalano
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Abstract

Semaphorins are involved in a wide range of biological processes, including axon guidance, neuronal migration, angiogenesis, cardio- and osteo-genesis. Recently they have also been found to be important for immune response. Sema3A reduces the activation of T cells through its cell-surface receptors, including members of the neuropilin and plexin families. By contrast, Sema4D (CD100), which is expressed on the surface of T, B and dendritic cells, increases B cell and dendritic cell function using either plexin B1 or CD72 as receptors. The transmembrane protein Sema4A is involved in the activation of immune cells through interactions with Tim-2. Emerging evidence also indicates that additional semaphorins and related molecules seem to function in the reciprocal stimulation of T cells and antigen-presenting cells (APCs). This paper discusses the functions of these semaphorins in the immune system, focusing on their roles in T cell-APC interactions.

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AnimalsAntigen-Presenting CellsAntigens, CDHumansImmunity, CellularNervous SystemNeuroimmunomodulationNeuronsSemaphorin-3ASemaphorinsT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Simona Moretti, Antonio Procopio, Massimo Boemi, Alfonso Catalano. 2006. Neuronal semaphorins regulate a primary immune response.. https://doi.org/10.2174/156720206778792939

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