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PubMed · 17109749

ProCAT: a data analysis approach for protein microarrays.

Xiaowei Zhu·Mark Gerstein·Michael Snyder
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Abstract

Protein microarrays provide a versatile method for the analysis of many protein biochemical activities. Existing DNA microarray analytical methods do not translate to protein microarrays due to differences between the technologies. Here we report a new approach, ProCAT, which corrects for background bias and spatial artifacts, identifies significant signals, filters nonspecific spots, and normalizes the resulting signal to protein abundance. ProCAT provides a powerful and flexible new approach for analyzing many types of protein microarrays.

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Cyclic AMP-Dependent Protein KinasesProtein Array AnalysisQuality ControlROC CurveSaccharomyces cerevisiaeSoftwareJournal ArticleResearch Support, N.I.H., Extramural

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Xiaowei Zhu, Mark Gerstein, Michael Snyder. 2006. ProCAT: a data analysis approach for protein microarrays.. https://doi.org/10.1186/gb-2006-7-11-r110

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