Polymorphic phospholipid phase transitions as tools to understand peptide-lipid interactions.

H Tournois; B de Kruijff

doi:10.1016/0009-3084(91)90084-o

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Polymorphic phospholipid phase transitions as tools to understand peptide-lipid interactions.

H Tournois·B de Kruijff

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Abstract

The effect of peptides on bilayer----non-bilayer phase transitions can be used as a tool to investigate the molecular aspects of peptide-lipid interactions. In this contribution the action on membranes of the peptide antibiotic gramicidin A and the bee venom component melittin are compared. Although the known structures and locations of these peptides upon membrane binding are very different, their actions on membranes show striking parallels. A general model is proposed that explains the seemingly complex peptide-lipid interactions by making use of simple concepts.

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Amino Acid Sequence Gramicidin Lipid Bilayers Melitten Membrane Fusion Membrane Lipids Models, Chemical Molecular Conformation Molecular Sequence Data Peptides Phospholipids Journal Article Review

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H Tournois, B de Kruijff. 1991. Polymorphic phospholipid phase transitions as tools to understand peptide-lipid interactions.. https://doi.org/10.1016/0009-3084(91)90084-o

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