[Conclusions, future prospects and recommendations].

D Bonnefont-Rousselot

doi:10.1016/s0003-4509(06)75336-6

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[Conclusions, future prospects and recommendations].

D Bonnefont-Rousselot

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Abstract

Understanding the notion of oxidative stress implies a good knowledge of the reactivity of the different reactive oxygen species (ROS). Cell damage can be induced by an overproduction of these species and/or by a deficiency in the protective antioxidant systems. Nevertheless, ROS do not display only deleterious effects and play key-roles in cell signalisation and regulation of the expression of redox sensitive genes. Besides ROS, reactive nitrogen species (RNS) with nitric oxide (*NO) as leader element, are widely involved in biology and lead to the term "nitrosative stress" that particularly describes the damage induced by peroxynitrite, a species formed by reaction between superoxide anion and degrees NO. Nutritional strategies have been based on antioxidant-rich diets, or on supplementation with antioxidants; they could constitute adjunct therapies of interest. Given all these data, radical biochemistry must be considered as a specific discipline.

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Animals Humans Oxidants Oxidative Stress Reactive Nitrogen Species Reactive Oxygen Species English Abstract Journal Article Review

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D Bonnefont-Rousselot. 2006. [Conclusions, future prospects and recommendations].. https://doi.org/10.1016/s0003-4509(06)75336-6

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