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Antiproliferative function of glia maturation factor beta.

R Lim·W X Zhong·A Zaheer
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Abstract

Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the mitogenic effect of acidic fibroblasts growth factor (aFGF), but the two are synergistic in promoting the morphologic differentiation of cultured astrocytes. GMF-beta also counteracts the growth-stimulating effect of pituitary extract and cholera toxin on Schwann cells. The results underscore the regulatory role of GMF-beta and its intricate interaction with the mitogenic growth factors.

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AnimalsAstrocytesCell CycleCell DivisionCell LineCells, CulturedDrug SynergismFibroblast Growth Factor 1Glia Maturation FactorGrowth InhibitorsKineticsNerve Tissue ProteinsRecombinant ProteinsSchwann CellsComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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R Lim, W X Zhong, A Zaheer. 1990. Antiproliferative function of glia maturation factor beta.. https://doi.org/10.1091/mbc.1.10.741

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