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PubMed · 17122786

A simple presurgical necrotizing enterocolitis-mortality scoring system.

U Kessler·A Mungnirandr·M Nelle·A F Nimmo·Z Zachariou·S Berger
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Abstract

OBJECTIVE: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). STUDY DESIGN: Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein). RESULTS: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively. CONCLUSION: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.

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Birth WeightEnterocolitis, NecrotizingFemaleGestational AgeHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLactic AcidMaleROC CurveRetrospective StudiesSensitivity and SpecificitySeverity of Illness IndexSurvival AnalysisJournal ArticleResearch Support, Non-U.S. Gov't

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U Kessler, A Mungnirandr, M Nelle, A F Nimmo, Z Zachariou, S Berger. 2006. A simple presurgical necrotizing enterocolitis-mortality scoring system.. https://doi.org/10.1038/sj.jp.7211613

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